|
KMID : 1100220060050010012
|
|
Dementia and Neurocognitive Disorders
2006 Volume.5 No. 1 p.12 ~ p.17
|
|
|
Neuropsychological Differences between Mild Cognitive Impairment and Mild Alzheimer’s Disease
|
|
Kim Woo-Jun
Yang Dong-Won
Shon Young-Min
Shim Yong-Soo
Cho Hyun
Kim Beum-Saeng
Kim Yeong-In
Lee Kwang-Soo
|
|
|
Abstract
|
|
|
Background: Mild cognitive impairment (MCI) refers to a transitional state between the cognition of normal aging and mild Alzheimer’s disease (AD). Several studies have indicated that MCI individuals are at an increased risk for developing AD with the rate of 10-15% per year. We investigated the neuropsychological differences between MCI and mild AD with clinical dementia rating (CDR) 0.5.
Methods: Twenty patients with MCI and 21 patients with AD of CDR 0.5 were recruited from the dementia clinic. Diagnoses were made for dementia and AD according to the Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition (DSM-IV), and the National Institute for Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders of Association (NINCDS-ADRDA) criteria for probable AD. We applied the working criteria for the dignoses of MCI. General cognitive function was evaluated by using the Korean version of Mini-Mental State Exam (K-MMSE), and Korean version of Hasegawa Dementia Scale (K-HDS). Severity of dementia was assessed using global CDR and CDR sum of boxes (SOB) score. Detailed neurocognitive functions were evaluated using the Seoul Neuropsychological Screening Battery (SNSB). All subjects were underwent brain MRI to detect any brain lesions that can affect cognition.
Results: Age, educational level and sex ratio did not differ between the two groups. CDR SOB scores were 1.1±0.8 for MCI group and 2.4±1.1 for mild AD group. The scores of K-MMSE, HDS-R, 3rd free recall of Seoul Verbal Learning Test (SVLT), Rey complex figure copy, remote memory, go-no-go test, word fluency test-category, and calculation were significantly lower in mild AD group.
Conclusion: Patients with mild AD showed poorer performance than patients with MCI in general cognition, visuospatial and frontal set shifting functions, verbal learning, naming, and calculation. These results suggest that the decline of cognitive functions occurs not only in memory, but also in frontal executive and visuospatial function in mild AD.
|
|
|
KEYWORD
|
|
|
Mild cognitive impairment, Alzheimer’s disease, Neuropsychological test
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|
|